Abstract
Objective: This study aimed to investigate the antipyretic and anti-inflammatory effectsand mechanisms of Sanchen Pediatric antipyretic Paste (SPAP).
Methods: Rats were randomly divided into 7 groups: negative control group, positive control group,positive treatment group, SPAP high-dose, medium-dose and low-dose groups, and blank substrategroup. Except normal control group, rats in other groups were subcutaneously injected with 10% dryyeast suspension (10 mL/kg) on the back to establish a fever model, and the normal group was giventhe same volume of saline. At the 4 h and 7 h after modeling, each treatment group was subjected tocorresponding SPAP intervention. Anal temperature was measured every one hour after modeling for10 consecutive times. The average temperature-rise curve, maximum temperature and body temperatureresponse index (TRI) were calculated to evaluate the efficacy of SPAP. After the last temperaturemeasurement, abdominal aortic blood was collected, and serum was separated from blood. Thelevels of IL-6, TNF-α and CRP in serum were determined by enzyme-linked immunosorbent assay.
Results: The body temperature of the positive control group was significantly increased (p < 0.01) 4hours after model establishment, and that of the SPAP groups significantly decreased (p < 0.01) after5 hours of the model establishment. The levels of Serum IL-6, TNF-α and CRP were significantlydecreased (p < 0.01) in a dose-dependent manner.
Conclusion: SPAP has an obvious antipyretic effect on fever caused by dry yeast in rats. One of itsantipyretic mechanisms may be associated with inhibiting inflammatory reactions by reducing theproduction or accelerating the degradation of endogenous thermogenic cytokines, such as IL-6, TNF-α, and CRP.
Keywords: Sanchen children antipyretic paste (SPAP), antipyretic effect, anti-inflammatory effect, IL-6, TNF-α, CRP
Graphical Abstract
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The Natural Products Journal
Title:Antipyretic and Anti-inflammatory Effects of Sanchen Pediatric AntipyreticPaste
Volume: 14 Issue: 5
Author(s): Li De Su, Hurilebater, Lu Men Chao, Sanchula, Dong Yu, Amguleng, Jian Hui Hao and Xin Li*
Affiliation:
- AffiliateHospital of Inner Mongolia University for the Nationalities, Tongliao, China
Keywords: Sanchen children antipyretic paste (SPAP), antipyretic effect, anti-inflammatory effect, IL-6, TNF-α, CRP
Abstract:
Objective: This study aimed to investigate the antipyretic and anti-inflammatory effectsand mechanisms of Sanchen Pediatric antipyretic Paste (SPAP).
Methods: Rats were randomly divided into 7 groups: negative control group, positive control group,positive treatment group, SPAP high-dose, medium-dose and low-dose groups, and blank substrategroup. Except normal control group, rats in other groups were subcutaneously injected with 10% dryyeast suspension (10 mL/kg) on the back to establish a fever model, and the normal group was giventhe same volume of saline. At the 4 h and 7 h after modeling, each treatment group was subjected tocorresponding SPAP intervention. Anal temperature was measured every one hour after modeling for10 consecutive times. The average temperature-rise curve, maximum temperature and body temperatureresponse index (TRI) were calculated to evaluate the efficacy of SPAP. After the last temperaturemeasurement, abdominal aortic blood was collected, and serum was separated from blood. Thelevels of IL-6, TNF-α and CRP in serum were determined by enzyme-linked immunosorbent assay.
Results: The body temperature of the positive control group was significantly increased (p < 0.01) 4hours after model establishment, and that of the SPAP groups significantly decreased (p < 0.01) after5 hours of the model establishment. The levels of Serum IL-6, TNF-α and CRP were significantlydecreased (p < 0.01) in a dose-dependent manner.
Conclusion: SPAP has an obvious antipyretic effect on fever caused by dry yeast in rats. One of itsantipyretic mechanisms may be associated with inhibiting inflammatory reactions by reducing theproduction or accelerating the degradation of endogenous thermogenic cytokines, such as IL-6, TNF-α, and CRP.
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Su Li De, Hurilebater , Chao Lu Men, Sanchula , Yu Dong, Amguleng , Hao Jian Hui and Li Xin*, Antipyretic and Anti-inflammatory Effects of Sanchen Pediatric AntipyreticPaste, The Natural Products Journal 2024; 14 (5) : e131023222197 . https://dx.doi.org/10.2174/0122103155253664231010070548
| DOI https://dx.doi.org/10.2174/0122103155253664231010070548 | Print ISSN 2210-3155 |
| Publisher Name Bentham Science Publisher | Online ISSN 2210-3163 |
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